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severe digestive problems, such as gastroparesis

Dulaglutide, sold under the brand name Trulicity among others, is a medication used for the treatment of type 2 diabetes in combination with diet and exercise.

Trulicity is a once-weekly injectable prescription medicine to improve blood sugar (glucose) in adults and children 10 years of age and older with type 2 diabetes mellitus. It should be used along with diet and exercise.

Avoid fried or fatty foods and foods high in sugar: These tend to be the toughest for your body to digest and the most likely to cause nausea while taking a GLP-1 medication. Eat slowly, and eat smaller meals. Eat foods that are light and bland. Drink clear or ice-cold drinks (like water or unsweetened tea).

Trulicity (dulaglutide) is not a form of insulin. It relies on people still having some functioning beta cells – these are cells in the pancreas that produce, store, and release insulin. Trulicity belongs to the class of medicines known as GLP-1 receptor agonists. It may also be called an incretin mimetic.

Dulaglutide is indicated to improve glycemic control in adults with type-2 diabetes mellitus as an adjunct to diet and exercise.

The 11 Trulicity Side Effects You Should Take Note of - GoodRx

Most commonly, kidney damage appears to happen in people experiencing severe nausea, vomiting, and diarrhea from Trulicity. These side effects can result in dehydration, which can lead to kidney damage or worsen existing kidney problems.

Serious side effects that have been reported with Trulicity include:

thyroid cancer

hypoglycemia (low blood sugar)

kidney problems.

pancreatitis (swelling of the pancreas)

allergic reaction

Side Effects of Trulicity | Trulicity (dulaglutide) Injection

Trulicity may cause tumors in the thyroid, including thyroid cancer. Watch for possible symptoms, such as a lump or swelling in the neck, trouble swallowing, hoarseness, or shortness of breath. If you have any of these symptoms, tell your healthcare provider.

Trulicity: 7 things you should know -

Trulicity does not take the place of insulin and is not effective in people with type 1 diabetes or for the treatment of diabetic ketoacidosis. Animal studies have reported thyroid C-cell tumors in rats given dulaglutide (the active ingredient of Trulicity).

Trulicity can be taken any time of day, with or without food. But it should be taken on the same day each week. Side effects like nausea, diarrhea, and abdominal pain are common with Trulicity. If you experience severe or bothersome side effects, talk to your healthcare provider


change in urination.

chest tightness.

decreased urine output.

difficulty with breathing or swallowing.


hives, itching, skin rash.


Studies have shown that Trulicity can lead to more weight loss than metformin alone. It's also been shown to cause more weight loss than sitagliptin (Januvia), another popular diabetes medication, when added to metformin. The amount of weight you can lose with Trulicity may depend on the dose.

Trulicity (dulaglutide): Uses, Side Effects, Dosage & Reviews

A low appetite is a known side effect of Trulicity (dulaglutide). Some people might also experience nausea, diarrhea, vomiting, and stomach pain, which can affect your appetite as well. These are common side effects of Trulicity (dulaglutide) and might occur during the first 2 to 3 days after taking the first dose.

Dulaglutide 4.5 mg demonstrated an effect on reduction in SBP and pulse pressure beyond that of dulaglutide 1.5 mg which was primarily weight mediated. Conclusions: Dulaglutide 1.5 mg reduced SBP and pulse pressure in people with T2D across the placebo-controlled trials in the AWARD program.

Trulicity starts working to treat your diabetes right after you inject it. But it may take a few weeks before you notice the drug helping to manage your blood sugar levels.

Trulicity: Side Effects, Usage, and Dosage Guide -

You should not use Trulicity if you are allergic to dulaglutide, or if you have: multiple endocrine neoplasia type 2 (tumors in your glands); a personal or family history of medullary thyroid carcinoma (a type of thyroid cancer); or. diabetic ketoacidosis (call your doctor for treatment).

TRULICITY is an injectable prescription medicine for adults with type 2 diabetes used to improve blood sugar (glucose) and used to reduce the risk of major cardiovascular events such as death, heart attack, or stroke in people who have heart disease or multiple cardiovascular risk factors.

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